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Protected Nucleosides

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General structures for Protected Nucleosides


Base-protected Nucleosides
Primary amine groups of nucleosidic bases covered by standard and labile protection groups.
  • Base-protected Nucleosides

    B = Base (A, C, G, etc)
    P = Me, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.
    X/Y = H, OH, F, OTBDMS, OMe, OMOE, O-Propargyl, NH2, etc.

  • DMT Protected Nucleoside

    B = Base (A, C, G, U, I, T, etc)
    P = Null, Me, halogen, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.
    X/Y = H, OH, F, OTBDMS, OMe, OMOE,
    O-Propargyl, NH2, etc.

  • TIPDS Protected Nucleoside

    B = Base (A, C, G, U, T, pU, T, iso-C, etc)
    P = Null, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, isotope, etc.
    X = OH, OMe, F, OMOE, etc

  • PMO Nucleoside

    B = Base (A, C, G, T, U)
    P = Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.

  • DMT/Base Protected 2'-O-4'-C-Locked Nucleoside

    B = Base (A, C, G, U, T, etc)
    P = Null, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.
    X = OH, ODMT.

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