Citations

Title	Publication	Authors	Cat.No.	Product Name
Identification of a key nucleotide influencing Cas12a crRNA activity for universal photo-controlled CRISPR diagnostics	Nat Commun.	Tian T, Xiao H, Guo X,..., Zhou X	PR1-008 PR2-007 PR3-008 PR5-003	DMT-2'-O-TBDMS-A(Bz)-CE-PhosphoramiditeDMT-2'-O-TBDMS-G(iBu)-CE-PhosphoramiditeDMT-2'-O-TBDMS-C(Ac)-CE-PhosphoramiditeDMT-2'-O-TBDMS-U-CE-Phosphoramidite
Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model	Mol Ther Nucleic Acids	Fakih HH, Tang Q, Summers A,..., Khvorova A	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2'-F-dA(Bz)-CE-PhosphoramiditeDMT-2'-F-dG(dmf)-CE-PhosphoramiditeDMT-2'-F-dG(iBu)-CE-PhosphoramiditeDMT-2'-F-dC(Ac)-CE PhosphoramiditeDMT-2'-F-dU-CE PhosphoramiditeDMT-2'-O-Me-A(Bz)-CE PhosphoramiditeDMT-2'-O-Me-G(dmf)-CE PhosphoramiditeDMT-2'-O-Me-G(iBu)-CE PhosphoramiditeDMT-2'-OMe-C(Ac)-CE-PhosphoramiditeDMT-2'-O-Me-U-CE Phosphoramidite
Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker	Pharmaceutics	Brylev VA, Ryabukhina EV, Nazarova EV,..., Korshun VA	PD1-004 PD2-004 PD2-006 PD3-003 PD3-007 PD4-002	DMT-dA(Bz)-CE-PhosphoramiditeDMT-dG(iBu)-CE-PhosphoramiditeDMT-dG(dmf)-CE-PhosphoramiditeDMT-dC(Bz)-CE-PhosphoramiditeDMT-dC(Ac)-CE-PhosphoramiditeDMT-dT-CE-Phosphoramidite
Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding	bioRxiv	Mathews EW, Coffey SR, Gärtner A,..., Carroll JB	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2'-F-dA(Bz)-CE-PhosphoramiditeDMT-2'-F-dG(dmf)-CE-PhosphoramiditeDMT-2'-F-dG(iBu)-CE-PhosphoramiditeDMT-2'-F-dC(Ac)-CE PhosphoramiditeDMT-2'-F-dU-CE PhosphoramiditeDMT-2'-O-Me-A(Bz)-CE PhosphoramiditeDMT-2'-O-Me-G(dmf)-CE PhosphoramiditeDMT-2'-O-Me-G(iBu)-CE PhosphoramiditeDMT-2'-OMe-C(Ac)-CE-PhosphoramiditeDMT-2'-O-Me-U-CE Phosphoramidite
AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution	Brief Bioinform	Gao Y, Zhu S, Li H,..., Qian Z	R5-027	N1-Me-pUTP, 100mM solution
Comprehensive Optimization of a Freeze-Drying Process Achieving Enhanced Long-Term Stability and In Vivo Performance of Lyophilized mRNA-LNPs	Int J Mol Sci.	Alejo T, Toro-Córdova A, Fernández L,..., de Miguel D.	ON-004 ON-039 ON-025 R1331 R2331 R3331 R5-027	T7 RNA polymeraseRibonuclease Inhibitor, Human PlacentaPyrophosphatase Inorganic (yeast)ATP 100mM solutionGTP 100mM solutionCTP 100mM solutionN1-Me-pUTP, 100mM solution
RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment	Nat Commun.	Shan X, Zhao Z, Lai P,..., Miao L	ON-004 R5-027	T7 RNA polymeraseN1-Me-pUTP, 100mM solution
Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy	Nat Commun.	Bai X, Chen Q, Li F,..., Zhang XQ	R5-022	pUTP, 100mM solution
An accurate and convenient method for Mycoplasma pneumoniae via one-step LAMP-CRISPR/Cas12b detection platform	Front Cell Infect Microbiol.	Liu T, Liu Q, Chen F,..., Chen Z	DN32	dNTP 25mM Mix
Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs	Mol Ther Nucleic Acids	Gilbert JW, Kennedy Z, Godinho BMDC,..., Khvorova A	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2'-F-dA(Bz)-CE-PhosphoramiditeDMT-2'-F-dG(dmf)-CE-PhosphoramiditeDMT-2'-F-dG(iBu)-CE-PhosphoramiditeDMT-2'-F-dC(Ac)-CE PhosphoramiditeDMT-2'-F-dU-CE PhosphoramiditeDMT-2'-O-Me-A(Bz)-CE PhosphoramiditeDMT-2'-O-Me-G(dmf)-CE PhosphoramiditeDMT-2'-O-Me-G(iBu)-CE PhosphoramiditeDMT-2'-OMe-C(Ac)-CE-PhosphoramiditeDMT-2'-O-Me-U-CE Phosphoramidite

A statistical-physics approach for codon usage optimisation	Comput Struct Biotechnol J.	Luna-Cerralbo D, Blasco-Machín I, Adame-Pérez S,..., Bruscolini P.	ON-124 ON-004 ON-039 ON-025 R1331 R2331 R3331 R5-027	BspQIT7 RNA polymeraseRibonuclease Inhibitor, Human PlacentaPyrophosphatase Inorganic (yeast)ATP 100mM solutionGTP 100mM solutionCTP 100mM solutionN1-Me-pUTP, 100mM solution
RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice	bioRxiv	Weiss A, Gilbert JW, Flores IVR,..., Khvorova A	ON-418	Cholesterol tetraethylene glycol (TetraEG) (plant source)
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation	bioRxiv	Miller R, Paquette J, Barker A,..., Aronin N	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2'-F-dA(Bz)-CE-PhosphoramiditeDMT-2'-F-dG(dmf)-CE-PhosphoramiditeDMT-2'-F-dG(iBu)-CE-PhosphoramiditeDMT-2'-F-dC(Ac)-CE PhosphoramiditeDMT-2'-F-dU-CE PhosphoramiditeDMT-2'-O-Me-A(Bz)-CE PhosphoramiditeDMT-2'-O-Me-G(dmf)-CE PhosphoramiditeDMT-2'-O-Me-G(iBu)-CE PhosphoramiditeDMT-2'-OMe-C(Ac)-CE-PhosphoramiditeDMT-2'-O-Me-U-CE Phosphoramidite
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates	Nucleic Acids Res.	Yu M, Qin J, Liu X,..., Nair JK	PR1-002 PR2-005 PR3-009 PR4-001	2'-O-4'-C-Locked-A(Bz) phosphoramidite2'-O-4'-C-Locked-G(dmf) Phosphoramidite2'-O-4'-C-Locked-5-Me-C(Bz) Phosphoramidite2'-O-4'-C-Locked-T Phosphoramidite
Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex	PLoS Pathog.	Du P, Huang L, Fang Y,..., Gao GF	ON-040 ON-257 ON-269	High Yield T7 RNA Synthesis KitCapped RNA Synthesis KitCapped RNA Synthesis Kit (with tailing)
Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses	Sci Rep.	Wang Z, Chen Y, Wu H,..., Liu Y	ON-062 RN31 ON-025 ON-039 ON-004 ON-028 ON-073 ON-074 ON-014 R2331	10X IVT Reaction BufferNTP 25mM MixPyrophosphatase Inorganic (yeast)Ribonuclease Inhibitor, Human PlacentaT7 RNA polymeraseVaccinia Capping Enzyme10X Capping BufferS-adenosylmethionine (SAM),32mMmRNA Cap-2'-O-MethyltransferaseGTP 100mM solution
Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies	Life Sci Alliance.	Wang J, Ma L, Chen Y,..., Cen S	R5-027	N1-Me-pUTP, 100mM solution
CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia	J Transl Med.	Yang N, Zhang C, Zhang Y,..., He Z.	ON-124 ON-124-G	BspQIBspQI (10U/ul)
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo	Nucleic Acids Res.	Zhang H, Kelly K, Lee J,..., Sontheimer EJ	ON-133	GalNAc-Cluster-COONa
An mRNA vaccine against rabies provides strong and durable protection in mice	Front Immunol.	Li M, Fang E, Wang Y,..., Li Y	ON-040	High Yield T7 RNA Synthesis Kit
Purification of linearized template plasmid DNA decreases double-stranded RNA formation during IVT reaction	Front Mol Biosci.	Martínez J, Lampaya V, Larraga A,..., Casabona D	R5-027	N1-Me-pUTP, 100mM solution
Ligand-based adoptive T cell targeting CA125 in ovarian cancer	J Transl Med.	Zhao H, Wu L, Dai J,..., Zhang L	ON-257 ON-269	Capped RNA Synthesis KitCapped RNA Synthesis Kit (with tailing)
Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases	Signal Transduct Target Ther.	Gu Y, Yang J, He C,..., Shi H	ON-124 ON-124-G	BspQIBspQI (10U/ul)
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo	Res Sq.	Hariharan VN, Caiazzi J, Miller R,..., Yamada K	PR5-001	DMT-2'-O-Me-U-CE Phosphoramidite
Algorithm for optimized mRNA design improves stability and immunogenicity	Nature	Zhang H, Zhang L, Lin A,..., Huang L	ON-109 ON-028 ON-179	DNase I (RNase-free)Vaccinia Capping EnzymeAlkaline Phosphatase, TAB5
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes	Nat Commun.	Subramanian M, McIninch J, Zlatev I,..., Jadhav V	PR1-002 PR2-005 PR2-003 PR3-009 PR5-006 PR4-001 D1-004 D3-003 R2-001 R5-002	2'-O-4'-C-Locked-A(Bz) phosphoramidite2'-O-4'-C-Locked-G(dmf) Phosphoramidite2'-O-4'-C-Locked-G(iBu)-CE Phosphoramidite2'-O-4'-C-Locked-5-Me-C(Bz) Phosphoramidite5'-O-DMTr-2'-O-4'-C-Locked-U Phosphoramidite2'-O-4'-C-Locked-T Phosphoramidite2'-F-dA2'-F-dC2'-OMe-Gr2'-OMe-Ur
Low Resource Integrated Platform for Production and Analysis of Capped mRNA	ACS Synth Biol.	Nwokeoji AO, Chou T, Nwokeoji EA	ON-028 ON-073	Vaccinia Capping Enzyme10X Capping Buffer
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts	Nat Biotechnol.	Dousis A, Ravichandran K, Hobert EM,..., Rabideau AE	R1331 R2331 R3331 R5331	ATP 100mM solutionGTP 100mM solutionCTP 100mM solutionUTP 100mM solution
Rational development of a combined mRNA vaccine against COVID-19 and influenza	NPJ Vaccines	Ye Q, Wu M, Zhou C,..., Qin CF	ON-028 ON-014	Vaccinia Capping EnzymemRNA Cap-2'-O-Methyltransferase
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity	Nucleic Acids Res.	Yamada K, Hildebrand S, Davis SM,..., Khvorova A	R5-003 D5-010	DMT-2'-OMe-UrDMT-2'-F-dU
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency	Ann Neurol.	Lopez-Gomez C, Sanchez-Quintero MJ, Lee EJ,..., Hirano M	PD3-003 PD3-007 PD4-002	DMT-dC(Bz)-CE-PhosphoramiditeDMT-dC(Ac)-CE-PhosphoramiditeDMT-dT-CE-Phosphoramidite
Quantification of T4-Like and T7-Like Cyanophages Using the Polony Method Show They Are Significant Members of the Virioplankton in the North Pacific Subtropical Gyre	Front Microbiol.	Goldin S, Hulata Y, Baran N, Lindell D	DN34	dNTP 2.5mM Mix
Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency	eBioMedicine	Lopez-Gomez C, Hewan H, Sierra C,..., Hirano M	D300 D400	2'-dC2'-dT
Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency	Ann Neurol.	Lopez-Gomez C, Levy RJ, Sanchez-Quintero MJ,..., Hirano M	D3100 D4100 D300 D400	dCMP·H2dTMP·H22'-dC2'-dT
Biosynthesis of 2′-Chloropentostatin and 2′-Amino-2′-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365	Appl Environ Microbiol.	Gao Y, Xu G, Wu P,..., Chen W	D6-002	2'-NH2-dI
An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis	Protein Cell	Chen W, Li Y, Li J,..., Zhou J	R5-012 D5-008 R5-011	5-Br-UMP·Na25-Br-dUMP·Na25-Me-UMP, Sodium Salt
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency	EMBO Mol Med.	Garone C, Garcia-Diaz B, Emmanuele V,..., Hirano M	D3100 D4100	dCMP·H2dTMP·H2
Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP	PLoS Pathog.	Lyu LD, Tang BK, Fan XY,..., Zhao GP	R5-046	5-OMe-UTP 100mM solution
Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae	PLoS Genet.	Zhou BO, Wang SS, Zhang Y,..., Zhou JQ	D3100 D3-005	dCMP·H25-Me-dCMP·Na2

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