引用文献

タイトル	出版物	著者	カタログ番号	製品名
Identification of a key nucleotide influencing Cas12a crRNA activity for universal photo-controlled CRISPR diagnostics	Nat Commun.	Tian T, Xiao H, Guo X, ..., Zhou X	PR1-008 PR2-007 PR3-008 PR5-003	DMT-2′-O-TBDMS-A(Bz)-CE-PhosphoramiditeDMT-2′-O-TBDMS-G(iBu)-CE-PhosphoramiditeDMT-2′-O-TBDMS-C(Ac)-CE-PhosphoramiditeDMT-2′-O-TBDMS-U-CE-Phosphoramidite
Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model	Mol Ther Nucleic Acids	Fakih HH, Tang Q, Summers A, ..., Khvorova A	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2′-F-dA(Bz)-CE-PhosphoramiditeDMT-2′-F-dG(dmf)-CE-PhosphoramiditeDMT-2′-F-dG(iBu)-CE-Phosphoramidite2′-F-Ac-dC-CE-Phosphoramidite2′-F-dU-CE-Phosphoramidite2′-OMe-Bz-A-CE-Phosphoramidite2′-OMe-dmf-G-CE-Phosphoramidite2′-OMe-iBu-G-CE-PhosphoramiditeDMT-2′-OMe-C(Ac)-CE-Phosphoramidite2′-OMe-U-CE-Phosphoramidite
Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker	Pharmaceutics	Brylev VA, Ryabukhina EV, Nazarova EV, ..., Korshun VA	PD1-004 PD2-004 PD2-006 PD3-003 PD3-007 PD4-002	DMT-dA(Bz)-CE-PhosphoramiditeDMT-dG(iBu)-CE-PhosphoramiditeDMT-dG(dmf)-CE-PhosphoramiditeDMT-dC(Bz)-CE-PhosphoramiditeDMT-dC(Ac)-CE-PhosphoramiditeDMT-dT-CE-Phosphoramidite
Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding	bioRxiv	Mathews EW, Coffey SR, Gärtner A, ..., Carroll JB	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2′-F-dA(Bz)-CE-PhosphoramiditeDMT-2′-F-dG(dmf)-CE-PhosphoramiditeDMT-2′-F-dG(iBu)-CE-Phosphoramidite2′-F-Ac-dC-CE-Phosphoramidite2′-F-dU-CE-Phosphoramidite2′-OMe-Bz-A-CE-Phosphoramidite2′-OMe-dmf-G-CE-Phosphoramidite2′-OMe-iBu-G-CE-PhosphoramiditeDMT-2′-OMe-C(Ac)-CE-Phosphoramidite2′-OMe-U-CE-Phosphoramidite
AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution	Brief Bioinform	Gao Y, Zhu S, Li H, ..., Qian Z	R5-042	N1-Me-pUTP, 100mM solution
Comprehensive Optimization of a Freeze-Drying Process Achieving Enhanced Long-Term Stability and In Vivo Performance of Lyophilized mRNA-LNPs	Int J Mol Sci.	Alejo T, Toro-Córdova A, Fernández L, ..., de Miguel D.	ON-004 ON-039 ON-025 R1-036 R2-039 R3-048 R5-042	T7 RNA polymeraseRibonuclease Inhibitor, Human PlacentaPyrophosphatase Inorganic (yeast)ATP 100mM solutionGTP 100mM solutionCTP 100mM solutionN1-Me-pUTP, 100mM solution
RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment	Nat Commun.	Shan X, Zhao Z, Lai P, ..., Miao L	ON-004 R5-042	T7 RNA polymeraseN1-Me-pUTP, 100mM solution
Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy	Nat Commun.	Bai X, Chen Q, Li F, ..., Zhang XQ	R5-022	pUTP, 100mM solution
An accurate and convenient method for Mycoplasma pneumoniae via one-step LAMP-CRISPR/Cas12b detection platform	Front Cell Infect Microbiol.	Liu T, Liu Q, Chen F, ..., Chen Z	DN32	dNTP 25mM Mix
Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs	Mol Ther Nucleic Acids	Gilbert JW, Kennedy Z, Godinho BMDC, ..., Khvorova A	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2′-F-dA(Bz)-CE-PhosphoramiditeDMT-2′-F-dG(dmf)-CE-PhosphoramiditeDMT-2′-F-dG(iBu)-CE-Phosphoramidite2′-F-Ac-dC-CE-Phosphoramidite2′-F-dU-CE-Phosphoramidite2′-OMe-Bz-A-CE-Phosphoramidite2′-OMe-dmf-G-CE-Phosphoramidite2′-OMe-iBu-G-CE-PhosphoramiditeDMT-2′-OMe-C(Ac)-CE-Phosphoramidite2′-OMe-U-CE-Phosphoramidite
A statistical-physics approach for codon usage optimisation	Comput Struct Biotechnol J.	Luna-Cerralbo D, Blasco-Machín I, Adame-Pérez S, ..., Bruscolini P.	ON-124 ON-004 ON-039 ON-025 R1-036 R2-039 R3-048 R5-042	BspQIT7 RNA polymeraseRibonuclease Inhibitor, Human PlacentaPyrophosphatase Inorganic (yeast)ATP 100mM solutionGTP 100mM solutionCTP 100mM solutionN1-Me-pUTP, 100mM solution
RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice	bioRxiv	Weiss A, Gilbert JW, Flores IVR, ..., Khvorova A	ON-418	Cholesterol tetraethylene glycol (TetraEG) (plant source)
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation	bioRxiv	Miller R, Paquette J, Barker A, ..., Aronin N	PD1-001 PD2-001 PD2-002 PD3-001 PD5-001 PR1-001 PR2-001 PR2-002 PR3-001 PR5-001	DMT-2′-F-dA(Bz)-CE-PhosphoramiditeDMT-2′-F-dG(dmf)-CE-PhosphoramiditeDMT-2′-F-dG(iBu)-CE-Phosphoramidite2′-F-Ac-dC-CE-Phosphoramidite2′-F-dU-CE-Phosphoramidite2′-OMe-Bz-A-CE-Phosphoramidite2′-OMe-dmf-G-CE-Phosphoramidite2′-OMe-iBu-G-CE-PhosphoramiditeDMT-2′-OMe-C(Ac)-CE-Phosphoramidite2′-OMe-U-CE-Phosphoramidite
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates	Nucleic Acids Res.	Yu M, Qin J, Liu X, ..., Nair JK	PR1-002 PR2-005 PR3-009 PR4-001	N6-Bz-2′-O-4′-C-Locked-Ar-CE-PhosphoramiditeN2-dmf-2′-O-4′-C-Locked-Gr-CE-PhosphoramiditeN4-Bz-2′-O-4′-C-Locked-5-Me-Cr-CE-Phosphoramidite2′-O-4′-C-Locked-Tr-CE-Phosphoramidite
Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex	PLoS Pathog.	Du P, Huang L, Fang Y, ..., Gao GF	ON-040 ON-257	High Yield T7 RNA Synthesis KitCapped RNA Synthesis Kit
Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses	Sci Rep.	Wang Z, Chen Y, Wu H, ..., Liu Y	ON-062-G RN31 ON-025 ON-039 ON-004 ON-028-G ON-073-G ON-074-G ON-014 R2-039	10X IVT Reaction BufferNTP 25mM MixPyrophosphatase Inorganic (yeast)Ribonuclease Inhibitor, Human PlacentaT7 RNA polymeraseVaccinia Capping Enzyme10X Capping BufferS-adenosylmethionine (SAM)mRNA Cap-2′-O-MethyltransferaseGTP 100mM solution
Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies	Life Sci Alliance.	Wang J, Ma L, Chen Y, ..., Cen S	R5-042	N1-Me-pUTP, 100mM solution
CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia	J Transl Med.	Yang N, Zhang C, Zhang Y, ..., He Z.	ON-124 ON-124-G	BspQIBspQI (10U/ul)
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo	Nucleic Acids Res.	Zhang H, Kelly K, Lee J, ..., Sontheimer EJ	ON-133	GalNAc-Cluster-COONa
An mRNA vaccine against rabies provides strong and durable protection in mice	Front Immunol.	Li M, Fang E, Wang Y, ..., Li Y	ON-040	High Yield T7 RNA Synthesis Kit
Purification of linearized template plasmid DNA decreases double-stranded RNA formation during IVT reaction	Front Mol Biosci.	Martínez J, Lampaya V, Larraga A, ..., Casabona D	R5-042	N1-Me-pUTP, 100mM solution
Ligand-based adoptive T cell targeting CA125 in ovarian cancer	J Transl Med.	Zhao H, Wu L, Dai J, ..., Zhang L	ON-257 ON-269	Capped RNA Synthesis KitCapped RNA Synthesis Kit (with tailing)
Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases	Signal Transduct Target Ther.	Gu Y, Yang J, He C, ..., Shi H	ON-124 ON-124-G	BspQIBspQI (10U/ul)
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo	Res Sq.	Hariharan VN, Caiazzi J, Miller R, ..., Yamada K	PR5-001	2′-OMe-U-CE-Phosphoramidite
Algorithm for optimized mRNA design improves stability and immunogenicity	Nature	Zhang H, Zhang L, Lin A, ..., Huang L	ON-109 ON-028-G ON-179	DNase I (RNase-free)Vaccinia Capping EnzymeAlkaline Phosphatase, TAB5
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes	Nat Commun.	Subramanian M, McIninch J, Zlatev I, ..., Jadhav V	PR1-002 PR2-005 PR2-003 PR3-009 PR5-006 PR4-001 D1-015 D3-003 R2-001 R5-002	N6-Bz-2′-O-4′-C-Locked-Ar-CE-PhosphoramiditeN2-dmf-2′-O-4′-C-Locked-Gr-CE-PhosphoramiditeN2-iBu-2′-O-4′-C-Locked-Gr-CE-PhosphoramiditeN4-Bz-2′-O-4′-C-Locked-5-Me-Cr-CE-Phosphoramidite2′-O-4′-C-Locked-Ur-CE-Phosphoramidite2′-O-4′-C-Locked-Tr-CE-Phosphoramidite2-NH2-2′-F-dA2′-F-dC2′-OMe-Gr2′-OMe-Ur
Low Resource Integrated Platform for Production and Analysis of Capped mRNA	ACS Synth Biol.	Nwokeoji AO, Chou T, Nwokeoji EA	ON-028-G ON-073-G	Vaccinia Capping Enzyme10X Capping Buffer
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts	Nat Biotechnol.	Dousis A, Ravichandran K, Hobert EM, ..., Rabideau AE	R1-036 R2-039 R3-048 R5-047	ATP 100mM solutionGTP 100mM solutionCTP 100mM solutionUTP 100mM solution
Rational development of a combined mRNA vaccine against COVID-19 and influenza	NPJ Vaccines	Ye Q, Wu M, Zhou C, ..., Qin CF	ON-028-G ON-014	Vaccinia Capping EnzymemRNA Cap-2′-O-Methyltransferase
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity	Nucleic Acids Res.	Yamada K, Hildebrand S, Davis SM, ..., Khvorova A	R5-003 D5-010	DMT-2′-OMe-UrDMT-2′-F-dU
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency	Ann Neurol.	Lopez-Gomez C, Sanchez-Quintero MJ, Lee EJ, ..., Hirano M	PD3-003 PD3-007 PD4-002	DMT-dC(Bz)-CE-PhosphoramiditeDMT-dC(Ac)-CE-PhosphoramiditeDMT-dT-CE-Phosphoramidite
Quantification of T4-Like and T7-Like Cyanophages Using the Polony Method Show They Are Significant Members of the Virioplankton in the North Pacific Subtropical Gyre	Front Microbiol.	Goldin S, Hulata Y, Baran N, Lindell D	DN34	dNTP 2.5mM Mix
Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency	eBioMedicine	Lopez-Gomez C, Hewan H, Sierra C, ..., Hirano M	D3-045 D4-012	2′-dC2′-dT
Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency	Ann Neurol.	Lopez-Gomez C, Levy RJ, Sanchez-Quintero MJ, ..., Hirano M	D3100 D4100 D3-045 D4-012	dCMP·H2dTMP·H22′-dC2′-dT
Biosynthesis of 2′-Chloropentostatin and 2′-Amino-2′-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365	Appl Environ Microbiol.	Gao Y, Xu G, Wu P, ..., Chen W	D6-002	2′-NH2-dI
An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis	Protein Cell	Chen W, Li Y, Li J, ..., Zhou J	R5-012 D5-008 R5-011	5-Br-UMP·Na25-Br-dUMP·Na25-Me-UMP, Sodium Salt
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency	EMBO Mol Med.	Garone C, Garcia-Diaz B, Emmanuele V, ..., Hirano M	D3100 D4100	dCMP·H2dTMP·H2
Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP	PLoS Pathog.	Lyu LD, Tang BK, Fan XY, ..., Zhao GP	R5-046	5-OMe-UTP 100mM solution
Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae	PLoS Genet.	Zhou BO, Wang SS, Zhang Y, ..., Zhou JQ	D3100 D3-005	dCMP·H25-Me-dCMP·Na2

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