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LNP Devices

R&D before scale-up allows the correct conditions to be found using a smaller, more economical and these conditions can then be used at later stages of production - reducing costs and improving time-to-market.

IJM NanoScaler


Process Overview


The IJM NanoScaler: a benchtop for lipid nanoparticle formulation


KNAUER's benchtop IJM NanoScaler system is designed for lipid nanoparticle R&D – allowing scientists to screen for the optimal process parameters for the formulation of API-containing lipid nanoparticles.


The IJM NanoScaler is made with research and development and lab-scale production in mind.


Equipped with our proven Impingement Jets Mixing (IJM) technology for the production of lipid nanoparticles the NanoScaler allows researchers to determine the optimum encapsulation conditions for their mRNA based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit.


The NanoScaler is made for low sample consumption so as not to waste valuable API. Its small footprint means it can comfortably sit on the benchtop of a research and development lab. The system comes with five different KNAUER Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of nucleotide encapsulation. In addition researchers can use their own custom mixing unit and benefit from the flexibility of the system set-up.


The encapsulation process can be remotely controlled by software; ran from a conventional PC or laptop, or even a tablet.