EN

GalNAc

 

 

GalNAc, short for N-Acetylgalactosamine, finds its application in targeted drug delivery, particularly for the liver. Here's how it works:

 

Target: GalNAc targets the Asialoglycoprotein Receptor (ASGPR) on liver cells. ASGPR is abundant and specifically recognizes GalNAc molecules.

 

Conjugation: GalNAc is attached to therapeutic molecules, such as siRNA (small interfering RNA) or antisense oligonucleotides (ASOs). These therapeutic molecules need a delivery system to reach their target site in the body.

 

Delivery: When the GalNAc-conjugated molecule is injected into the bloodstream, the GalNAc moiety acts like a key that unlocks the ASGPR on liver cells. This specific interaction allows the therapeutic molecule to be efficiently delivered into the liver cells.

Filter

E-catalog

0 product(s) in total

ON-133.svg

GalNAc-Cluster-COONa

Catalog No. ON-133
Molecular Formula: C60H107N7O33 (free acid)
OP-042.svg

GalNAc-Cluster-HHA-CE Phosphoramidite

Catalog No. OP-042
Molecular Formula: C93H155N10O43P
ON-383.svg

Peracetylated GalNAc Pentenoic Acid

Catalog No. ON-383
Molecular Formula: C19H29NO11
CAS No. 1159408-54-4
ON-431.svg

TEG-GalNAc Cluster Succinate CPG (500Å)

Catalog No. ON-431
Molecular Formula: /
ON-468.svg

TEG-GalNAc Cluster Succinate CPG (1000Å)

Catalog No. ON-468
Molecular Formula: /
ON-287.svg

TEG-GalNAc Cluster Succinate

Catalog No. ON-287
Molecular Formula: C56H76N2O21
OP-123.svg

TEG-GalNAc Cluster Amidite

Catalog No. OP-123
Molecular Formula: C61H89N4O19P
ON-491.svg

Peracetylated GalNAc PEG linker-Azide

Catalog No. ON-491
Molecular Formula: C22H36N4O12
ON-530.svg

Peracetylated GalNAc PEG linker-Amino

Catalog No. ON-530
Molecular Formula: C22H38N2O12 (free acid)
ON-778

Peracetylated GalNAc Butanoic Acid

Catalog No. ON-778
Molecular Formula: C18H27NO11
OP-213

Peracetylated β-D-glucoside-TEG-phosphoramidite

Catalog No. OP-213
Molecular Formula: C29H49N2O14P